Nutlin-3 |CAS:890090-75-2 Probechem Biochemicals

Chemical Structure : Nutlin-3

CAS No.: 890090-75-2

加入收藏

Nutlin-3 (Nutlin 3;Nutlin3)

货号: PC-45845Not For Human Use, Lab Use Only.

Nutlin-3 (Nutlin 3) is a potent and selective Mdm2 inhibitor with IC50 of 90 nM.

规格	价格	库存
5 mg (Free Sample)	￥180	In stock
10 mg	￥880	In stock
25 mg	￥1380	In stock
50 mg	￥2280	In stock
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

Nutlin-3 (Nutlin 3) is a potent and selective Mdm2 inhibitor with IC50 of 90 nM.
Nutlin-3 binds MDM2 in the p53-binding pocket and activates the p53 pathway in cancer cells, leading to cell cycle arrest, apoptosis, and growth inhibition of human tumor xenografts in nude mice.
Nutlin-3 induces p53 and p21WAF expression in a dose-dependent manner in 22RV1 cells.
Nutlin-3 also can block the MDMX-p53 interaction and induce the p53 pathway in retinoblastoma cells (Weri1) with IC50 of 0.7 uM.

物理化学性质&存储条件

分子量	581.4896
分子式	C30H30Cl2N4O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-Piperazinone, 4-[[(4R,5S)-4,5-bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-, rel-

参考文献

1. Vassilev LT, et al. Science. 2004 Feb 6;303(5659):844-8.

2. Supiot S, et al. Mol Cancer Ther. 2008 Apr;7(4):993-9.

3. Laurie NA, et al. Nature, 2006, 444(7115), 61-66.

Nutlin-3 (Nutlin 3;Nutlin3)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Nutlin-3 (Nutlin 3;Nutlin3)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.