Pifithrin-β |CAS:60477-34-1 Probechem Biochemicals

Chemical Structure : Pifithrin-β

CAS No.: 60477-34-1

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Pifithrin-β (Cyclic Pifithrin-α;PFT-β)

货号: PC-45047Not For Human Use, Lab Use Only.

Pifithrin-β is a cyclic analog of Pifithrin-α and a small molecule inhibitor of p53.

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10 mg	￥980	In stock
25 mg	￥1580	In stock
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生物&药学活性

Pifithrin-β is a cyclic analog of Pifithrin-α and a small molecule inhibitor of p53.
Pifithrin-β prevents dexamethasone-induced cell death in murine thymocytes with EC50 of 2.01 uM.
Pifithrin-β sensitizes p53-deficient tumors to radiotherapy and chemotherapy and increases apoptosis in cancer cells.

物理化学性质&存储条件

分子量	268.3766
分子式	C16H16N2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Imidazo[2,1-b]benzothiazole, 5,6,7,8-tetrahydro-2-(4-methylphenyl)-

参考文献

1. Pietrancosta N, et al. Bioorg Med Chem Lett. 2005 Mar 15;15(6):1561-4.

2. Barchéchath SD, et al. J Med Chem. 2005 Oct 6;48(20):6409-22.

3. Zuco V, et al. Neoplasia. 2008 Jun;10(6):587-96.

Pifithrin-β (Cyclic Pifithrin-α;PFT-β)

生物&药学活性

物理化学性质&存储条件

参考文献

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Pifithrin-β (Cyclic Pifithrin-α;PFT-β)

生物&药学活性

物理化学性质&存储条件

参考文献

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