| Cat. No. |
Product Name |
Information |
| PC-72829 |
ALRN-6924
MDM2/MDMX inhibitor
|
Sulanemadlin (ALRN-6924, MP-4897) is a potent dual inhibitor of MDM2/MDM, inhibits p53-MDM2, p53-MDMX, or both p53 and MDM2 and MDMX protein-protein interactions. |
| PC-72590 |
ReACp53
p53 mutants rescuer
|
ReACp53 is a cell-penetrating 17-residue peptide designed to inhibit p53 amyloid formation, rescues p53 function in cancer cell lines. |
| PC-72589 |
ADH-6
p53 mutants rescuer
|
ADH-6 is a small molceule that abrogates amyloid formation of aggregation-prone region of mutant p53 DBD with binding Ki of 366 nM (p53 mutant R248W DBD-derived peptide, pR248W). |
| PC-38124 |
NSC194598
p53 inhibitor
|
NSC194598 is a specific small molecule inhibitor that inhibits p53 sequence-specific DNA binding in vitro (IC50=180 nM) and in vivo. |
| PC-38075 |
H210
Mdm2/MdmX inhibitor
|
H210 is a potent dual Mdm2/MdmX inhibitor with Ki of 9.66/2.89 nM, respectively.. |
| PC-38074 |
H203
Mdm2/MdmX inhibitor
|
H203 is a potent dual Mdm2/MdmX inhibitor with Ki of 2/11 nM, respectively. |
| PC-35309 |
MB710
p53 Y220C reactivator
|
MB710 is a small-molecule p53 mutant Y220C stabilizer, binds tightly to the Y220C pocket (Kd=4 uM) and stabilizes p53-Y220C in vitro. |
| PC-35308 |
MB725
p53 Y220C reactivator
|
MB725 is a small-molecule p53 mutant Y220C stabilizer, induces selective viability reduction in several p53-Y220C cancer cell lines (Huh7 cell IC50=10 uM). |
| PC-42959 |
Navtemadlin
MDM2-p53 inhibitor
|
Navtemadlin (AMG-232) is a potent, selective, orally bioavailable MDM2-p53 inhibitor with Kd of 0.045 nM, inhibits SJSA-1 cell proliferation with IC50 of 9.1 nM. |
| PC-42949 |
YH239-EE
MDM2-p53 inhibitor
|
YH239-EE is the ethyl ester of YH239, which is a highly potent, selective MDM2-p53 antagonist with Ki of 300 nM, shows no affinity for MDM4. |
| PC-42840 |
Serdemetan
HDM2 inhibitor
|
Serdemetan (JNJ 26854165) is an anticancer agent that inhibits the function of the E3 ligase HDM2, dose-dependently inhibits proliferation in both wild-type and mutant p53 cell lines with IC50 of 0.25-3 uM. |
| PC-63188 |
AQ-101
MDM2 degrader
|
AQ-101 is a novel small-molecule anthraquinone analog that induces MDM2 protein degradation (Kd=0.37 uM) through a self-ubiquitination and proteasome-mediated mechanism, leading to activation of p53. |
