| Cat. No. |
Product Name |
Information |
| PC-63188 |
AQ-101
MDM2 degrader
|
AQ-101 is a novel small-molecule anthraquinone analog that induces MDM2 protein degradation (Kd=0.37 uM) through a self-ubiquitination and proteasome-mediated mechanism, leading to activation of p53. |
| PC-62777 |
RETRA
p53 activator
|
RETRA is a small molecule mutant p53 reactivator that activates a set of p53-regulated genes and specifically suppresses mutant p53-bearing tumor cells in vitro and in mouse xenograft. |
| PC-62555 |
MMRi6
Mdm2-MdmX inhibitor
|
MMRi6 is a small molecule inhibitor that disrupts Mdm2-MdmX RING-RING interaction interactions in vitro and activates p53 in cancer cells.. |
| PC-62554 |
MMRi64
Mdm2-MdmX inhibitor
|
MMRi64 is a small molecule inhibitor that disrupts Mdm2-MdmX RING-RING interaction interactions in vitro and activates p53 in cancer cells. |
| PC-62500 |
ISA27
p53-MDM2 inhibitor
|
ISA27 is a novel small molecule that blocks p53-MDM2 interaction and induces apoptosis both in vitro and in vivo. |
| PC-62499 |
SM13
p53-MDM2 inhibitor
|
SM13 is a novel small molecule that blocks p53-MDM2 interaction and induces apoptosis both in vitro and in vivo. |
| PC-62406 |
APR-246
p53 activator
|
APR-246 (Eprenetapopt, PRIMA-1MET) is a methylated derivative of PRIMA-1 that restores mutant p53 activity, acts synergistically with chemotherapeutic agents to inhibit tumor cell proliferation. |
| PC-62280 |
MS7972
p53-CBP inhibitor
|
MS7972 is a small molecules that blocks p53 and CREB binding protein (CBP) association, completely blocks CBP BRD/p53-AcK382 interactions at 50 uM, results in loss of p53 phosphorylation at Ser15 as well as acetylation at Lys382. |
| PC-62260 |
Alrizomadlin
MDM2 inhibitor
|
Alrizomadlin (APG-115) is a potent and orally active MDM2 inhibitor with Ki <1 nM, potently inhibits SJSA-1 cell growth with IC50 of 60 nM. |
| PC-62117 |
ML379
TP53 mutant inhibitor
|
ML379 (CID71576758) is a potent, selective TP53 mutant cancer cells inhibitor with IC50 of 13 nM in sensitive HeLa cells (TP53 mutant). |
| PC-62086 |
MI 219
MDM2-p53 inhibitor
|
MI 219 is a potent, specific MDM2-p53 inhibitor with Ki of 5 nM, >10,000-fold selective for MDM2 over MDMX. |
| PC-62085 |
P53R3
p53 activator
|
P53R3 is a novel p53 reactivator that restores sequence-specific DNA binding of the endogenously expressed p53(R175H) and p53(R273H) mutants in gel-shift assays. |
