MB725 |CAS:2230058-99-6 Probechem Biochemicals

Chemical Structure : MB725

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MB725 (MB-725)

货号: PC-35308Not For Human Use, Lab Use Only.

MB725 is a small-molecule p53 mutant Y220C stabilizer, induces selective viability reduction in several p53-Y220C cancer cell lines (Huh7 cell IC50=10 uM).

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生物&药学活性

MB725 is a small-molecule p53 mutant Y220C stabilizer, induces selective viability reduction in several p53-Y220C cancer cell lines (Huh7 cell IC50=10 uM)。
MB725 caused reduction of viability correlated with increased and selective transcription of p53 target genes such as BTG2, p21, PUMA, FAS, TNF, and TNFRSF10B, which promote apoptosis and cell cycle arrest, suggesting compound-mediated transcriptional activation of the Y220C mutant.

物理化学性质&存储条件

分子量	484.356
分子式	C18H21IN4O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(diethylamino)-N-ethyl-5-hydroxy-6-iodo-7-(1H-pyrrol-1-yl)benzo[d]thiazole-4-carboxamide

参考文献

1. Baud MGJ, et al. Eur J Med Chem. 2018 May 25;152:101-114.

MB725 (MB-725)

生物&药学活性

物理化学性质&存储条件

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MB725 (MB-725)

生物&药学活性

物理化学性质&存储条件

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