YH239-EE |CAS:1364488-67-4 Probechem Biochemicals

Chemical Structure : YH239-EE

CAS No.: 1364488-67-4

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YH239-EE (YH 239-EE;YH 239 EE)

货号: PC-42949Not For Human Use, Lab Use Only.

YH239-EE is the ethyl ester of YH239, which is a highly potent, selective MDM2-p53 antagonist with Ki of 300 nM, shows no affinity for MDM4.

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10 mg	￥980	In stock
25 mg	￥1580	In stock
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生物&药学活性

YH239-EE is the ethyl ester of YH239, which is a highly potent, selective MDM2-p53 antagonist with Ki of 300 nM, shows no affinity for MDM4.
YH239-EE induces apoptosis in AML cells and patient samples, induces p53 and activates the apoptotic caspase 3/7 in MOLM-13 (wt-p53) cells.

物理化学性质&存储条件

分子量	504.4056
分子式	C25H27Cl2N3O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 55 mg/mL
Chemical Name/SMILES	1H-Indole-2-carboxylic acid, 6-chloro-3-[1-[[(4-chlorophenyl)methyl]formylamino]-2-[(1,1-dimethylethyl)amino]-2-oxoethyl]-, ethyl ester

参考文献

1. Huang Y, et al. ACS Chem Biol. 2014 Mar 21;9(3):802-11.

YH239-EE (YH 239-EE;YH 239 EE)

生物&药学活性

物理化学性质&存储条件

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YH239-EE (YH 239-EE;YH 239 EE)

生物&药学活性

物理化学性质&存储条件

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