ReACp53

Chemical Structure : ReACp53

CAS No.:

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货号: PC-72590Not For Human Use, Lab Use Only.

ReACp53 is a cell-penetrating 17-residue peptide designed to inhibit p53 amyloid formation, rescues p53 function in cancer cell lines.

规格	价格	库存
5 mg	￥1980	In stock
10 mg	￥3280	In stock
25 mg	￥5480	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

ReACp53 is a cell-penetrating 17-residue peptide designed to inhibit p53 amyloid formation, rescues p53 function in cancer cell lines.
ReACp53 inhibits p53 aggregation in primary cells from HGSOC patients, and re-localizes p53 to the nucleus in an active conformation.
ReACp53 induces cancer cell death, cell cycle arrest and results in p53 degradation.
ReACp53 induces rapid cell death in human primary uterine fibroblasts transfected with a dominant negative R175H p53 mutant grown in 3D.
ReACp53 specifically affects cell viability and proliferation of cancer cells bearing mutant p53 but not wild type when grown as organoids.
ReACp53 causes regression of xenografts bearing an aggregation-prone p53 mutant in HGSOC xenograft models.
ReACp53 is well tolerated, causes regression of intraperitonal disseminated tumors in vivo.

物理化学性质&存储条件

分子量	2617.13
分子式	C108H206N52O24
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO (26.2 mg/mL)
Chemical Name/SMILES	NH2-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Pro-Ile-Leu-Thr-Arg-Ile-Thr-Leu-Glu-COOH

参考文献

1. Soragni A, et al. Cancer Cell. 2016 Jan 11; 29(1):90-103.

2. Neal A, et al. Cancers (Basel). 2021 Nov 24;13(23):5908.

3. Zhang Y, et al. Oncogene. 2017 Sep 28;36(39):5473-5483.

ReACp53

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ReACp53

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