H203 | Mdm2/MdmX inhibitor |Probechem Biochemicals

Chemical Structure : H203

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H203 (dual Mdm2/MdmX inhibitor H203)

货号: PC-38074Not For Human Use, Lab Use Only.

H203 is a potent dual Mdm2/MdmX inhibitor with Ki of 2/11 nM, respectively.

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生物&药学活性

H203 is a potent dual Mdm2/MdmX inhibitor with Ki of 2/11 nM, respectively.
H203 significantly reduced cell viability in the cells overexpressing both Mdm2 and MdmX, and a significant and dose-dependent decrease in cell number in H203-treated cells lacking Mdm2 or MdmX.
H203-mediated decrease in cell viability is strictly p53-dependent and H203 affects MdmX more specifically than nutlin-3a.
H203 induced the expression of the p21 gene but not the p53 gene in treated cancer cells.

物理化学性质&存储条件

分子量	667.547
分子式	C35H28Cl2N6O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	8-((4S,5R)-4,5-bis(4-chlorophenyl)-1-(3-oxopiperazine-1-carbonyl)-4,5-dihydro-1H-imidazol-2-yl)-1-phenyl-3,4-dihydro-1H-benzo[e][1,4]diazepine-2,5-dione

参考文献

1. Xiyao Cheng, et al. Nat Commun. 2022 Feb 28;13(1):1087.

H203 (dual Mdm2/MdmX inhibitor H203)

生物&药学活性

物理化学性质&存储条件

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H203 (dual Mdm2/MdmX inhibitor H203)

生物&药学活性

物理化学性质&存储条件

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