AQ-101 |CAS:1353384-61-8 Probechem Biochemicals

Chemical Structure : AQ-101

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AQ-101 (AQ101)

货号: PC-63188Not For Human Use, Lab Use Only.

AQ-101 is a novel small-molecule anthraquinone analog that induces MDM2 protein degradation (Kd=0.37 uM) through a self-ubiquitination and proteasome-mediated mechanism, leading to activation of p53.

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生物&药学活性

AQ-101 is a novel small-molecule anthraquinone analog that induces MDM2 protein degradation (Kd=0.37 uM) through a self-ubiquitination and proteasome-mediated mechanism, leading to activation of p53.
AQ-101 induces apoptosis of acute lymphoblastic leukemia (ALL) especially those with a wild-type p53 phenotype and MDM2 expression in vitro and in vivo.
AQ-101 inhibits development of ALL in nude or SCID mice with a human ALL xenograft.

物理化学性质&存储条件

分子量	331.708
分子式	C16H10ClNO5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-chloro-N-(4,5-dihydroxy-9,10-dioxo-9,10-dihydroanthracen-2-yl)acetamide

参考文献

1. Gu L, et al. Mol Cancer Ther. 2018 Feb;17(2):497-507.

AQ-101 (AQ101)

生物&药学活性

物理化学性质&存储条件

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AQ-101 (AQ101)

生物&药学活性

物理化学性质&存储条件

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