| Cat. No. |
Product Name |
Information |
| PC-62260 |
Alrizomadlin
MDM2 inhibitor
|
Alrizomadlin (APG-115, AA-115) is a potent and orally active MDM2 inhibitor with Ki <1 nM, potently inhibits SJSA-1 cell growth with IC50 of 60 nM. |
| PC-62117 |
ML379
TP53 mutant inhibitor
|
ML379 (CID71576758) is a potent, selective TP53 mutant cancer cells inhibitor with IC50 of 13 nM in sensitive HeLa cells (TP53 mutant). |
| PC-62086 |
MI 219
MDM2-p53 inhibitor
|
MI 219 is a potent, specific MDM2-p53 inhibitor with Ki of 5 nM, >10,000-fold selective for MDM2 over MDMX. |
| PC-62085 |
P53R3
p53 activator
|
P53R3 is a novel p53 reactivator that restores sequence-specific DNA binding of the endogenously expressed p53(R175H) and p53(R273H) mutants in gel-shift assays. |
| PC-62084 |
SCH 529074
p53 activator
|
SCH 529074 is a small molecule mutant p53 reactivator that binds p53 DNA binding domain with Kd of 1-2 uM. |
| PC-62083 |
STIMA 1
p53 activator
|
STIMA 1 is a small molecule mutant p53 reactivator that can stimulate mutant p53 DNA binding in vitro, induces expression of p53 target proteins and triggers apoptosis in mutant p53-expressing human tumor cells.. |
| PC-62082 |
CP-31398 dihydrochloride
p53 activator
|
CP-31398 (CP31398) dihydrochloride is a small molecule p53 reactivator that protects p53 from thermal denaturation, not only reactivates mutant p53 but also induces stabilization of wild type p53. |
| PC-62081 |
PK7088
p53 Y220C reactivator
|
PK-7088 is a small molecule mutant p53 Y220C reactivator, promotes correct folding of Y220 mutant p53 and induces expression of p53 targets p21 and the Noxa, triggers nuclear export of the pro-apoptotic Bax protein to mitochondria. |
| PC-62020 |
RO 2443
Mdm2-MdmX inhibitor
|
RO 2443 is a potent, dual MDM2/MDMX antagonist that inhibits both MDM2 (IC50=33 nM) and MDMX (IC50=41 nM) binding to p53, but poor water solubility does not allow for a meaningful assessment of its cellular activity.. |
| PC-61497 |
SLMP53-1
p53 reactivator
|
SLMP53-1 is a small molecule reactivator of wild-type and mutant p53, shows a p53-dependent anti-proliferative activity in human wt and mut p53R280K-expressing tumor cells. |
| PC-61496 |
DIMP53-1
p53-MDM2/X inhibitor
|
DIMP53-1 is a novel small-molecule dual inhibitor of p53-MDM2/X interactions by potentially binding to p53, without effect on other MDM. |
| PC-61495 |
PK11007
p53 activator
|
PK11007 (PK 11007) is a 2-sulfonylpyrimidine compound that is a mild thiol alkylator with anticancer activity toward p53-compromised cells, stabilizes p53 in vitro via selective alkylation. |
