Alrizomadlin (APG-115) | MDM2 inhibitor | Probechem Biochemicals

Chemical Structure : Alrizomadlin

CAS No.: 1818393-16-6

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Alrizomadlin (APG-115, APG115, AA115, AA-115)

货号: PC-62260Not For Human Use, Lab Use Only.

Alrizomadlin (APG-115, AA-115) is a potent and orally active MDM2 inhibitor with Ki <1 nM, potently inhibits SJSA-1 cell growth with IC50 of 60 nM.

规格	价格	库存
5 mg	￥780	In stock
10 mg	￥1180	In stock
25 mg	￥1980	In stock
50 mg	￥3280	In stock
100 mg		Get quote

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生物&药学活性

Alrizomadlin (APG-115, AA-115) is a potent and orally active MDM2 inhibitor with Ki <1 nM, potently inhibits SJSA-1 cell growth with IC50 of 60 nM.
Alrizomadlin (APG-115) exhibits IC50 values of 38, 18, and 104 nM in the RS4;11 acute leukemia, LNCaP prostate cancer, and HCT116 colon cancer cell lines, respectively.
Alrizomadlin (APG-115) effectively inhibits tumor growth and causes no or minimal weight loss.

物理化学性质&存储条件

分子量	642.593
分子式	C34H38Cl2FN3O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-((3'R,4'S,5'R)-6''-chloro-4'-(3-chloro-2-fluorophenyl)-1'-ethyl-2''-oxodispiro[cyclohexane-1,2'-pyrrolidine-3',3''-indoline]-5'-carboxamido)bicyclo[2.2.2]octane-1-carboxylic acid

参考文献

1. Aguilar A, et al. J Med Chem. 2017 Apr 13;60(7):2819-2839.

Alrizomadlin (APG-115, APG115, AA115, AA-115)

生物&药学活性

物理化学性质&存储条件

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Alrizomadlin (APG-115, APG115, AA115, AA-115)

生物&药学活性

物理化学性质&存储条件

参考文献

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