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首页-小分子抑制剂&激动剂-Apoptosis-MDM2-p53-APR-246
APR-246

Chemical Structure : APR-246

CAS No.: 5291-32-7

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APR-246 (Eprenetapopt, PRIMA-1MET, APR246)

货号: PC-62406Not For Human Use, Lab Use Only.

APR-246 (Eprenetapopt, PRIMA-1MET) is a methylated derivative of PRIMA-1 that restores mutant p53 activity, acts synergistically with chemotherapeutic agents to inhibit tumor cell proliferation.

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10 mg ￥980 In stock
25 mg ￥1480 In stock
50 mg ￥2380 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

APR-246 (Eprenetapopt, PRIMA-1MET) is a methylated derivative of PRIMA-1 that restores mutant p53 activity, acts synergistically with chemotherapeutic agents to inhibit tumor cell proliferation.
APR-246 (Eprenetapopt, PRIMA-1MET) also restores the pro-apoptotic function to mutant TAp63γ and TAp73β in tumor cells but has less effect on TAp73α.
APR-246 (Eprenetapopt, PRIMA-1MET) induces mutant p53-dependent mitochondria-mediated apoptosis through activation of caspase-2 with subsequent cytochrome c release and further activation of downstream caspase-9 and caspase-3.
APR-246 (Eprenetapopt, PRIMA-1MET) inhibits tumor xenograft growth in vivo.

物理化学性质&存储条件

分子量 199.25
分子式 C10H17NO3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-(Hydroxymethyl)-2-(methoxymethyl)-1-azabicyclo[2.2.2]octan-3-one

参考文献

1. Shen J, et al. Oncogene. 2008 Nov 20;27(51):6571-80.

2. Bykov VJ, et al. Oncogene. 2005 May 12;24(21):3484-91.

3. Rökaeus N, et al. Oncogene. 2010 Dec 9;29(49):6442-51.

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