ML379 |CAS:1630760-58-5 Probechem Biochemicals

Chemical Structure : ML379

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ML379 (CID71576758)

货号: PC-62117Not For Human Use, Lab Use Only.

ML379 (CID71576758) is a potent, selective TP53 mutant cancer cells inhibitor with IC50 of 13 nM in sensitive HeLa cells (TP53 mutant).

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生物&药学活性

ML379 (CID71576758) is a potent, selective TP53 mutant cancer cells inhibitor with IC50 of 13 nM in sensitive HeLa cells (TP53 mutant).
ML379 displays >1,000-fold selectivity over insensitive A549 cells (TP53 wild type).
ML379 displays low nM activity in a larger panel of TP53 mutant cell lines.

物理化学性质&存储条件

分子量	273.33
分子式	C15H19N3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-5-Methyl-6-(4-morpholinophenyl)-4,5-dihydropyridazin-3(2H)-one

参考文献

1. Lewis TA, et al. Probe Reports from the NIH Molecular Libraries Program [Internet].

ML379 (CID71576758)

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物理化学性质&存储条件

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ML379 (CID71576758)

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