SM13 |CAS:1445992-93-7 Probechem Biochemicals

Chemical Structure : SM13

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SM13 (p53-MDM2 inhibitor SM13)

货号: PC-62499Not For Human Use, Lab Use Only.

SM13 is a novel small molecule that blocks p53-MDM2 interaction and induces apoptosis both in vitro and in vivo.

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生物&药学活性

SM13 is a novel small molecule that blocks p53-MDM2 interaction and induces apoptosis both in vitro and in vivo.
SM13 reduces cell proliferation and induces apoptosis in vitro in cells carrying either p53 WT or mutated gene, suggesting that its effect is independent from p53 transcriptional activity.
SM13 induces cancer cell death in a dose-dependent manner through the activation of the mitochondrial-dependent death signalling in p53-mutated cells.
SM13 reduces tumour growth in vivo.

物理化学性质&存储条件

分子量	481.405
分子式	C21H25BrN2O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-bromo-3'-(cyclohexane carbonyl)-1-methyl-2-oxospiro[indoline-3,2'-thiazolidine

参考文献

1. Sorriento D, et al. Br J Cancer. 2015 Jan 6;112(1):77-85.

SM13 (p53-MDM2 inhibitor SM13)

生物&药学活性

物理化学性质&存储条件

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SM13 (p53-MDM2 inhibitor SM13)

生物&药学活性

物理化学性质&存储条件

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