MDM2/p53 compound (inhibitors, antagonists, agonists)-ProbeChem.com

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Cat. No.	Product Name	Information
PC-22936	RITA p53/HDM-2 inhibitor	RITA is a small molecule inhibitor of the protein-protein interaction between p53 and human double minute-2 (HDM-2), binds to p53 with an apparent Kd value of 1.5 nM and prevents the interaction between p53 and HDM-2.
PC-22898	MX69-102 MDM2 degrader	MX69-102 is a small molecule MDM2 degrader that induces MDM2 self-ubiquitination and protein degradation, binds to the MDM2 C-terminal RING domain with ITC Kd of 0.39 uM.
PC-21238	DS-3032 tosylate hydrate MDM2-p53 inhibitor	Milademetan (DS-3032b) is a potent, selective, orally available MDM2-p53 inhibitor with potential antineoplastic activity.
PC-20687	MMRi67 MDM2-MDM4 E3 ligase inhibitor	MMRi67 is a potent E3 ligase inhibitor of the MDM2-MDM4 E3 complex, inhibits RING-RING interaction of MDM4 and MDM2B with Kd of 896 nM.
PC-62080	RETRA hydrochloride	RETRA hydrochloride is a small molecule mutant p53 reactivator that activates a set of p53-regulated genes and specifically suppresses mutant p53-bearing tumor cells in vitro and in mouse xenograft.
PC-62079	RETRA hydrobromide	RETRA hydrobromide is a small molecule mutant p53 reactivator that activates a set of p53-regulated genes and specifically suppresses mutant p53-bearing tumor cells in vitro and in mouse xenograft.

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