MMRi67

Chemical Structure : MMRi67

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货号: PC-20687Not For Human Use, Lab Use Only.

MMRi67 is a potent E3 ligase inhibitor of the MDM2-MDM4 E3 complex, inhibits RING-RING interaction of MDM4 and MDM2B with Kd of 896 nM.

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生物&药学活性

MMRi67 is a potent E3 ligase inhibitor of the MDM2-MDM4 E3 complex, inhibits RING-RING interaction of MDM4 and MDM2B with Kd of 896 nM.
MMRi67 inhibited ubiquitination of every component of the ternary complex, MDM2, MDM4, and p53, in a dose-dependent manner.
MMRi67 induced p53 protein accumulation in NALM6 cells, inhibited leukemic cell proliferation with IC50 of 4.58 uM, by inducing p53-independent apoptosis with low toxicity for healthy peripheral blood monocytes (PBMCs).

物理化学性质&存储条件

分子量	405.84
分子式	C22H16ClN3O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	O=C(O)C1=CC=C(C(C2=CC(Cl)=C3C=CC=NC3=C2O)NC4=NC=CC=C4)C=C1

参考文献

1. Rati Lama, et al. Front Oncol. 2022 Aug 5;12:933446.

MMRi67

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物理化学性质&存储条件

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MMRi67

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