RETRA hydrobromide |CAS:1035875-01-4 Probechem Biochemicals

Chemical Structure : RETRA hydrobromide

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RETRA hydrobromide

货号: PC-62079Not For Human Use, Lab Use Only.

RETRA hydrobromide is a small molecule mutant p53 reactivator that activates a set of p53-regulated genes and specifically suppresses mutant p53-bearing tumor cells in vitro and in mouse xenograft.

规格	价格	库存	数量
100 mg		Get quote
250 mg		Get quote
500 mg		Get quote
1 g		Get quote

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生物&药学活性

RETRA hydrobromide is a small molecule mutant p53 reactivator that activates a set of p53-regulated genes and specifically suppresses mutant p53-bearing tumor cells in vitro and in mouse xenograft; increases in the expression level of p73, releases p73 and poduces tumor-suppressor effects similar to the functional reactivation of p53; a p73 activator.

物理化学性质&存储条件

分子量	350.245
分子式	C11N11NO3S2.HBr
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(4,5-dihydro-1,3-thiazol-2-ylthio)-1-(3,4-dihydroxyphenyl)ethanone hydrobromide

参考文献

1. Kravchenko JE, et al. Proc Natl Acad Sci U S A. 2008 Apr 29;105(17):6302-7.

2. Sonnemann J, et al. Eur J Cancer. 2015 May;51(7):841-51.

3. Santag S, et al. Oncogene. 2013 Aug 8;32(32):3676-85.