MX69-102

Chemical Structure : MX69-102

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货号: PC-22898Not For Human Use, Lab Use Only.

MX69-102 is a small molecule MDM2 degrader that induces MDM2 self-ubiquitination and protein degradation, binds to the MDM2 C-terminal RING domain with ITC Kd of 0.39 uM.

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生物&药学活性

MX69-102 is a small molecule MDM2 degrader that induces MDM2 self-ubiquitination and protein degradation, binds to the MDM2 C-terminal RING domain with ITC Kd of 0.39 uM.
MX69-102 does not bind to MDM2 with deletion of the RING.
MX69-102 potently downregulated MDM2 in MDM2-overexpressing ALL cell lines.
MX69-102 mediated MDM2 downregulation, leading to activation of p53 and inhibition of XIAP.
MX69-102 shows potent inhibitory and apoptotic effects on MDM2-overexpressing ALL in vitro.
MX69-102 exhibits minimal or no cytotoxic or inhibitory effect on normal human hematopoiesis.
MX69-102 also shows effective inhibition on xenografted human MDM2-overexpressing ALL in SCID mice.

物理化学性质&存储条件

分子量	518.63
分子式	C29H30N2O5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(3aS,4R,9bS)-N-(4-acetylphenyl)-4-(4-isobutyrylphenyl)-2,3,3a,4,5,9b-hexahydrofuro[3,2-c]quinoline-8-sulfonamide

参考文献

1. Tao Liu, et al. Cancer Lett. 2024 Jul 23:598:217126.

MX69-102

生物&药学活性

物理化学性质&存储条件

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MX69-102

生物&药学活性

物理化学性质&存储条件

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