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首页-小分子抑制剂&激动剂-Apoptosis-MDM2-p53-RITA
RITA

Chemical Structure : RITA

CAS No.: 213261-59-7

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RITA (NSC 652287)

货号: PC-22936Not For Human Use, Lab Use Only.

RITA is a small molecule inhibitor of the protein-protein interaction between p53 and human double minute-2 (HDM-2), binds to p53 with an apparent Kd value of 1.5 nM and prevents the interaction between p53 and HDM-2.

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10 mg ￥980 In stock
25 mg ￥1680 In stock
50 mg ￥2680 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

RITA is a small molecule inhibitor of the protein-protein interaction between p53 and human double minute-2 (HDM-2), binds to p53 with an apparent Kd value of 1.5 nM and prevents the interaction between p53 and HDM-2.
RITA induces DNA damage and apoptosis in, as well as inhibits the growth of, A498, TK-10, ACHN, and UO-31 renal carcinoma cells (GI50s = 0.017, 0.032, 22.76, and 41.71 µM, respectively).
RITA (10 mg/kg) reduces tumor volume in an HCT116 mouse xenograft model.
RITA (45 mg/kg) induces complete tumor regression in an A498 mouse xenograft model when administered at a dose of 45 mg/kg.

物理化学性质&存储条件

分子量 292.37
分子式 C14H12O3S2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(5,5'-(Furan-2,5-diyl)bis(thiophene-5,2-diyl))dimethanol

参考文献

1. Chène, P, et al. Nat. Rev. Cancer 3, 102-109 (2003).

2. Issaeva, N., et al. Nat. Med. 10(12), 1321-1328 (2004).

3. Rivera, M.I., et al. Biochem. Pharmacol. 57(11), 1283-1295 (1999).

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