| Cat. No. |
Product Name |
Information |
| PC-60466 |
CTX-1
p53-HdmX inhibitor
|
A novel small molecule that overcomes HdmX-mediated p53 repression, binds directly to HdmX (Kd=450 nM) to prevent p53-HdmX complex formation. |
| PC-60462 |
SP 141
MDM2 inhibitor
|
A novel specific MDM2 inhibitor that promotes MDM2 auto-ubiquitination and degradation. |
| PC-60443 |
RO-5963
Mdm2-MdmX inhibitor
|
RO-5963 is a potent, dual MDM2/MDMX-p53 interaction inhibitor with IC50 of 17 and 24 nM, respectively. |
| PC-60442 |
AM-8735
MDM2-p53 inhibitor
|
AM-8735 is a potent MDM2-p53 interaction inhibitor with remarkable biochemical (HTRF IC50=0.4 nM), cellular potency (SJSA-1 EdU IC50=25 nM), and favorable pharmacokinetic properties. |
| PC-60441 |
AM-8553
MDM2-p53 inhibitor
|
AM-8553 is a potent, selective, orally bioavailable MDM2-p53 interaction inhibitor with HTRF IC50 of 1.1 nM, SJSA-1 EdU IC50 of 68 nM. |
| PC-60440 |
AM-6761
MDM2-p53 inhibitor
|
AM-6761 is a potent MDM2-p53 interaction inhibitor with remarkable biochemical (HTRF IC50=0.1 nM), cellular potency (SJSA-1 EdU IC50=16 nM), and favorable pharmacokinetic properties. |
| PC-60439 |
TDP-665759
HDM2-p53 inhibitor
|
TDP-665759 is a small molecule inhibitor of HDM2-p53 interaction with FP IC50 of 0.7 uM. |
| PC-60438 |
NU-8165
MDM2-p53 inhibitor
|
NU-8165 is a small molecule inhibitor of MDM2-p53 protein-protein interaction with IC50 of 16 uM. |
| PC-60437 |
NU-8231
MDM2-p53 inhibitor
|
NU-8231 is a small molecule inhibitor of MDM2-p53 protein-protein interaction with IC50 of 5.3 uM in ELISA assay. |
| PC-60436 |
WK-298
Mdm2-MdmX inhibitor
|
WK-298 (Novartis 101) is a potent small molecule inhibitor that binds and disrupts the MDM2/MDMX-p53 interaction with IC50 of 0.19 uM and 19.7 uM, respectively. |
| PC-60304 |
RO-5353
p53-MDM2 inhibitor
|
RO-5353 is a potent, selective, and orally active p53-MDM2 antagonist with IC50 of 7 nM. |
| PC-60303 |
RO-2468
p53-MDM2 inhibitor
|
RO-2468 (RO2468) potent, selective, and orally active p53-MDM2 antagonist with IC50 of 6 nM. |
