RO 2443 |CAS:1416663-79-0 Probechem Biochemicals

Chemical Structure : RO 2443

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RO 2443 (RO2443)

货号: PC-62020Not For Human Use, Lab Use Only.

RO 2443 is a potent, dual MDM2/MDMX antagonist that inhibits both MDM2 (IC50=33 nM) and MDMX (IC50=41 nM) binding to p53, but poor water solubility does not allow for a meaningful assessment of its cellular activity..

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生物&药学活性

RO 2443 is a potent, dual MDM2/MDMX antagonist that inhibits both MDM2 (IC50=33 nM) and MDMX (IC50=41 nM) binding to p53, but poor water solubility does not allow for a meaningful assessment of its cellular activity.

物理化学性质&存储条件

分子量	401.798
分子式	C20H14ClF2N3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2,4-Imidazolidinedione, 5-[(6-chloro-7-methyl-1H-indol-3-yl)methylene]-3-[(3,4-difluorophenyl)methyl]-

参考文献

1. Graves B, et al. Proc Natl Acad Sci U S A. 2012 Jul 17;109(29):11788-93.

RO 2443 (RO2443)

生物&药学活性

物理化学性质&存储条件

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RO 2443 (RO2443)

生物&药学活性

物理化学性质&存储条件

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