COTI-2 |CAS:1039455-84-9 Probechem Biochemicals

Chemical Structure : COTI-2

CAS No.: 1039455-84-9

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COTI-2 (COTI2)

货号: PC-61494Not For Human Use, Lab Use Only.

COTI-2 (COTI2) is an orally available thiosemicarbazone that may act on mutant forms of p53 and PI3K/AKT/mTOR pathway.

规格	价格	库存
5 mg	￥780	In stock
10 mg	￥1180	In stock
25 mg	￥1880	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

COTI-2 (COTI2) is an orally available thiosemicarbazone that may act on mutant forms of p53 and PI3K/AKT/mTOR pathway.
COTI-2 induces apoptosis in a wide variety of human tumor cells in culture (IC50s<40 nM), inhibits the proliferation of colorectal cancer cell lines more effectively than cetuximab and erlotinib.
COTI-2 shows superior activity against tumor, and is safe and well-tolerated in vivo.

物理化学性质&存储条件

分子量	366.5
分子式	C19H22N6S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(2-pyridinyl)-2-(6,7-dihydro-8(5H)-quinolinylidene)hydrazide-1-piperazinecarbothioic acid

参考文献

1. Salim KY, et al. Oncotarget. 2016 Jul 5;7(27):41363-41379.

2. Duffy MJ, et al. Eur J Cancer. 2017 Jul 27;83:258-265.

3. Heffeter P, et al. Antioxid Redox Signal. 2018 Jan 15. doi: 10.1089/ars.2017.7487.

COTI-2 (COTI2)

生物&药学活性

物理化学性质&存储条件

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COTI-2 (COTI2)

生物&药学活性

物理化学性质&存储条件

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