AM-7209 |CAS:1623432-51-8 Probechem Biochemicals

Chemical Structure : AM-7209

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AM-7209 (AM 7209;AM7209)

货号: PC-60982Not For Human Use, Lab Use Only.

AM-7209 is a potent and selective inhibitor of the MDM2-p53 interaction with Kd of 38 pM, and IC50 of 1.6 nM.

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生物&药学活性

AM-7209 is a potent and selective inhibitor of the MDM2-p53 interaction with Kd of 38 pM, and IC50 of 1.6 nM.
AM-7209 potently inhibits cell growth on-target in the tumor cell line with wild-type p53 cell with IC50 of 2 nM, exhibits >12,500-fold selectivity over those with p53-deficient cells.
AM-7209 demonstrates remarkable pharmacokinetic properties and in vivo antitumor activity in both the SJSA-1 osteosarcoma xenograft model (ED50=2.6 mg/kg QD) and the HCT-116 colorectal carcinoma xenograft model (ED50=10 mg/kg QD).

物理化学性质&存储条件

分子量	747.7
分子式	C37H41Cl2FN2O7S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(2-((3R,5R,6S)-1-((S)-2-(tert-Butylsulfonyl)-1-cyclopropylethyl)-6-(4-chloro-3-fluorophenyl)-5-(3-chlorophenyl)-3- methyl-2-oxopiperidin-3-yl)acetamido)-2-methoxybenzoic Acid

参考文献

1. Rew Y, et al. J Med Chem. 2014 Dec 26;57(24):10499-511.

AM-7209 (AM 7209;AM7209)

生物&药学活性

物理化学性质&存储条件

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AM-7209 (AM 7209;AM7209)

生物&药学活性

物理化学性质&存储条件

参考文献

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