CTX-1 |CAS:501935-96-2 Probechem Biochemicals

Chemical Structure : CTX-1

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CTX-1 (CTX1;NSC 363260)

货号: PC-60466Not For Human Use, Lab Use Only.

A novel small molecule that overcomes HdmX-mediated p53 repression, binds directly to HdmX (Kd=450 nM) to prevent p53-HdmX complex formation.

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生物&药学活性

CTX-1 (NSC 363260) is a small molecule that overcomes HdmX-mediated p53 repression, binds directly to HdmX (Kd=450 nM) to prevent p53-HdmX complex formation.
CTX-1 results in the rapid induction of p53 in a DNA damage-independent manner, induces apoptosis or suppresses proliferation in a panel of cancer cells (LD50=1-10 uM).
CTX-1 exhibits high in vivo activity in a mouse model of circulating primary human leukemia.

物理化学性质&存储条件

分子量	234.26
分子式	C14H10N4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3,6-diaminoacridine-9-carbonitrile

参考文献

1. Karan G, et al. Mol Cancer Ther. 2016 Apr;15(4):574-582.

CTX-1 (CTX1;NSC 363260)

生物&药学活性

物理化学性质&存储条件

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CTX-1 (CTX1;NSC 363260)

生物&药学活性

物理化学性质&存储条件

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