HL001 |CAS:1186371-31-2 Probechem Biochemicals

Chemical Structure : HL001

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HL001 (HL 001)

货号: PC-61324Not For Human Use, Lab Use Only.

HL001 (HL 001) is a potent cyclophilin A (CypA) inhibitor with IC50 of 31.6 nM, induces NSCLC cell cycle arrest and apoptosis via restoring p53 expression.

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生物&药学活性

HL001 (HL 001) is a potent cyclophilin A (CypA) inhibitor with IC50 of 31.6 nM, induces NSCLC cell cycle arrest and apoptosis via restoring p53 expression.
HL001 stabilizes p53 through inhibiting the MDM2-mediated p53 ubiquitination, and downregulates G3BP1 and induces ROS and DNA damage.
HL001 selectively suppresses tumor growth in p53 wild-type NSCLC harboring p53-72R through disrupting interaction between MDM2 and p53-72R in a CypA-dependent manner.
HL001 synergistically enhance tumor regression in orthotopic NSCLC mouse model combined with cisplatin.

物理化学性质&存储条件

分子量	360.369
分子式	C21H16N2O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-((9H-fluoren-9-yl)carbamoyl)-2,6-dihydroxybenzamide

参考文献

1. Lu W, et al. Oncogene. 2017 Aug 17;36(33):4719-4731.

2. Ni S, et al. J Med Chem. 2009 Sep 10;52(17):5295-8.

HL001 (HL 001)

生物&药学活性

物理化学性质&存储条件

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HL001 (HL 001)

生物&药学活性

物理化学性质&存储条件

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