DIMP53-1 |CAS: 2968308-60-1 Probechem Biochemicals

Chemical Structure : DIMP53-1

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DIMP53-1 (DIMP 53-1)

货号: PC-61496Not For Human Use, Lab Use Only.

DIMP53-1 is a novel small-molecule dual inhibitor of p53-MDM2/X interactions by potentially binding to p53, without effect on other MDM.

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生物&药学活性

DIMP53-1 is a novel small-molecule dual inhibitor of p53-MDM2/X interactions by potentially binding to p53, without effect on other MDM.
DIMP 53-1 causes growth inhibition, mediated by p53 stabilization and upregulation of p53 transcriptional targets involved in cell cycle arrest and apoptosis.
DIMP 53-1 shows a p53-dependent antitumor activity in human tumor xenograft mice models; a novel p53 activator.

物理化学性质&存储条件

分子量	408.501
分子式	C27H24N2O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(3S,9bR)-3-((1-benzyl-1H-indol-3-yl)methyl)-9b-methyl-2,3-dihydrooxazolo[2,3-a]isoindol-5(9bH)-one

参考文献

1. Soares J, et al. Mol Oncol. 2017 Jun;11(6):612-627.

DIMP53-1 (DIMP 53-1)

生物&药学活性

物理化学性质&存储条件

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DIMP53-1 (DIMP 53-1)

生物&药学活性

物理化学性质&存储条件

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