ISA27 |CAS:1254366-73-8 Probechem Biochemicals

Chemical Structure : ISA27

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ISA27 (ISA 27)

货号: PC-62500Not For Human Use, Lab Use Only.

ISA27 is a novel small molecule that blocks p53-MDM2 interaction and induces apoptosis both in vitro and in vivo.

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生物&药学活性

ISA27 is a novel small molecule that blocks p53-MDM2 interaction and induces apoptosis both in vitro and in vivo.
ISA27 reduces cell proliferation and induces apoptosis in vitro in cells carrying either p53 WT or mutated gene, suggesting that its effect is independent from p53 transcriptional activity.
ISA27 induces cancer cell death in a dose-dependent manner through the activation of the mitochondrial-dependent death signalling in p53-mutated cells.

物理化学性质&存储条件

分子量	399.849
分子式	C19H14ClN3O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(3R,7aR)-6-(4-chlorobenzyl)-1H-spiro[imidazo[1,5-c]thiazole-3,3'-indoline]-2',5,7(6H,7aH)-trione

参考文献

1. Sorriento D, et al. Br J Cancer. 2015 Jan 6;112(1):77-85.

ISA27 (ISA 27)

生物&药学活性

物理化学性质&存储条件

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ISA27 (ISA 27)

生物&药学活性

物理化学性质&存储条件

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