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首页-小分子抑制剂&激动剂-Apoptosis-MDM2-p53-SCH 529074
SCH 529074

Chemical Structure : SCH 529074

CAS No.: 922150-11-6

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SCH 529074 (SCH529074)

货号: PC-62084Not For Human Use, Lab Use Only.

SCH 529074 is a small molecule mutant p53 reactivator that binds p53 DNA binding domain with Kd of 1-2 uM.

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5 mg ￥1780 In stock
10 mg ￥2980 In stock
25 mg ￥4980 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

SCH 529074 is a small molecule mutant p53 reactivator that binds p53 DNA binding domain with Kd of 1-2 uM.
SCH 529074 restores growth-suppressive function to mutant p53 and inhibits ubiquitination of p53 by HDM2.

物理化学性质&存储条件

分子量 563.6
分子式 C31H36Cl2N6
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N3-[2-[[4-[Bis(4-chlorophenyl)methyl]-1-piperazinyl]methyl]-4-quinazolinyl]-N1,N1-dimethyl-1,3-propanediamine

参考文献

1. Demma M, et al. J Biol Chem. 2010 Apr 2;285(14):10198-212.

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