MMRi64 |CAS:430458-66-5 Probechem Biochemicals

Chemical Structure : MMRi64

CAS No.: 430458-66-5

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MMRi64 (Mdm2-MdmX inhibitor MMRi64)

货号: PC-62554Not For Human Use, Lab Use Only.

MMRi64 is a small molecule inhibitor that disrupts Mdm2-MdmX RING-RING interaction interactions in vitro and activates p53 in cancer cells.

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5 mg	￥1380	In stock
10 mg	￥2180	In stock
25 mg	￥3680	In stock
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100 mg		Get quote

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生物&药学活性

MMRi64 is a small molecule inhibitor that disrupts Mdm2-MdmX RING-RING interaction interactions in vitro and activates p53 in cancer cells.
MMRi64 potently induces downregulation of Mdm2 and MdmX in leukemia cells, only induces the expression of pro-apoptotic gene PUMA (p53 upregulated modulator of apoptosis) with minimal induction of growth-arresting gene p21.
MMRi64 selectively induces the apoptotic arm of the p53 pathway in leukemia/lymphoma cells; synergistically induces p53 and apoptosis in combination with Nutlin3a.

物理化学性质&存储条件

分子量	410.298
分子式	C22H17Cl2N3O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	7-[(2,3-Dichlorophenyl)[(4-methyl-2-pyridinyl)amino]methyl]-8-quinolinol

参考文献

1. Wu W, et al. Cell Death Dis. 2015 Dec 31;6:e2035.

MMRi64 (Mdm2-MdmX inhibitor MMRi64)

生物&药学活性

物理化学性质&存储条件

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MMRi64 (Mdm2-MdmX inhibitor MMRi64)

生物&药学活性

物理化学性质&存储条件

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