欢迎访问ProbeChem中文网站，英文网站请访问www.probechem.com
    英文 |     中文

产品咨询: sales@probechem.com
订购: order@probechem.com

首页-小分子抑制剂&激动剂-Apoptosis-MDM2-p53-ALRN-6924
ALRN-6924

Chemical Structure : ALRN-6924

CAS No.: 1451199-98-6

加入收藏

ALRN-6924 (Sulanemadlin, ALRN6924, MP-4897)

货号: PC-72829Not For Human Use, Lab Use Only.

ALRN-6924 (Sulanemadlin) is a potent dual inhibitor of MDM2/MDM, inhibits p53-MDM2, p53-MDMX, or both p53 and MDM2 and MDMX protein-protein interactions.

规格 价格 库存 数量
2 mg ￥2480 In stock
5 mg ￥3980 In stock
10 mg ￥5980 In stock
25 mg ￥9580 In stock
50 mg Get quote
100 mg Get quote
获取报价单
* 请选择数量再加入购物车
 or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

ALRN-6924 (Sulanemadlin) is a potent dual inhibitor of MDM2/MDM, inhibits p53-MDM2, p53-MDMX, or both p53 and MDM2 and MDMX protein-protein interactions.
ALRN-6924 demonstrated potent anti-proliferative activity in a dose-dependent manner in two ER+ cell lines with WT TP53, MCF-7 and ZR-75-1, with IC50 values of 113 nM and 500 nM respectively.
The combination of ALRN-6924 and chemotherapeutic agents synergistically inhibit cell proliferation in vitro, ALRN-6924 combined with paclitaxel reactivates p53 and induces cell cycle arrest and apoptosis in vitro.
ALRN-6924 mutually enhances both paclitaxel and eribulin antitumor efficacy and inhibits tumor growth in vivo.

物理化学性质&存储条件

分子量 1930.28
分子式 C95H140N20O23
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

42,112-(7E)-7-Undecene-1,11-diyl-N-acetyl-L-leucyl-L-threonyl-L-phenylalanyl-L-alanyl-L-α-glutamyl-L-tyrosyl-L-tryptophyl-L-alanyl-L-glutaminyl-L-leucyl-D-alanyl-L-alanyl-L-alanyl-L-alanyl-L-alanyl-L-alanyl-D-alaninamide

参考文献

1. Pairawan S, et al. Breast Cancer Res. 2021 Mar 4;23(1):29.

2. Liao G, et al. Eur J Med Chem. 2018 Nov 5;159:1-9.

3. Saleh MN, et al. Clin Cancer Res. 2021 Jul 22:clincanres.0715.2021.

备案号：沪ICP备16042516号-1 Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

联系我们 sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

询单

  • *产品名称:
  • *姓名:
  • *邮箱:
  • *公司名称:
  • *询单数量:
  • *国籍:
  • 询单信息: