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首页-小分子抑制剂&激动剂-Apoptosis-MDM2-p53-Serdemetan
Serdemetan

Chemical Structure : Serdemetan

CAS No.: 881202-45-5

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Serdemetan (JNJ 26854165;JNJ26854165;JNJ-26854165)

货号: PC-42840Not For Human Use, Lab Use Only.

Serdemetan (JNJ 26854165) is an anticancer agent that inhibits the function of the E3 ligase HDM2, dose-dependently inhibits proliferation in both wild-type and mutant p53 cell lines with IC50 of 0.25-3 uM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Serdemetan (JNJ 26854165) is an anticancer agent that inhibits the function of the E3 ligase HDM2, dose-dependently inhibits proliferation in both wild-type and mutant p53 cell lines with IC50 of 0.25-3 uM.
Serdemetan (JNJ 26854165) induces p53-mediated apoptosis in acute leukemia cells with wild-type p53, accelerates the proteasome-mediated degradation of p21 and antagonizes the transcriptional induction of p21 by p53, induces S-phase delay and upregulates E2F1 expression in p53 mutant cells.
Serdemetan (JNJ 26854165) demonstrates radiosensitizing activity in vitro and in tumor xenografts.

物理化学性质&存储条件

分子量 328.4103
分子式 C21H20N4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1,4-Benzenediamine, N1-[2-(1H-indol-3-yl)ethyl]-N4-4-pyridinyl-

参考文献

1. Kojima K, et al. Mol Cancer Ther. 2010 Sep;9(9):2545-57.

2. Tabernero J, et al. Clin Cancer Res. 2011 Oct 1;17(19):6313-21.

3. Chargari C, et al. Cancer Lett. 2011 Dec 22;312(2):209-18.

4. Jones RJ, et al. J Pharmacol Exp Ther. 2013 Sep;346(3):381-92.

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