欢迎访问ProbeChem中文网站，英文网站请访问www.probechem.com
    英文 |     中文

产品咨询: sales@probechem.com
订购: order@probechem.com

首页-小分子抑制剂&激动剂-Apoptosis-MDM2-p53-ADH-6
ADH-6

Chemical Structure : ADH-6

CAS No.: 2227429-65-2

加入收藏

ADH-6 (ADH6)

货号: PC-72589Not For Human Use, Lab Use Only.

ADH-6 is a small molceule that abrogates amyloid formation of aggregation-prone region of mutant p53 DBD with binding Ki of 366 nM (p53 mutant R248W DBD-derived peptide, pR248W).

规格 价格 库存 数量
2 mg ￥2680 In stock
5 mg ￥4680 In stock
10 mg ￥7580 In stock
50 mg Get quote
100 mg Get quote
获取报价单
* 请选择数量再加入购物车
 or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

ADH-6 is a small molceule that abrogates amyloid formation of aggregation-prone region of mutant p53 DBD with binding Ki of 366 nM (p53 mutant R248W DBD-derived peptide, pR248W).
ADH-6 (5 uM) dissociates mutant p53 aggregates in in MIA PaCa-2 cells, ADH-6 efficiently enters cells to directly interact with and stabilize mutant p53.
ADH-6 causes selective cytotoxicity in cancer cells bearing mutant p53, reduced MIA PaCa-2 cell viability in a concentration-dependent manner, with EC50 of 2.7 and 2.5 uM at 24 and 48 h incubation times, respectively.
ADH-6 decreased cell viability of human cancer cells harboring other aggregation-prone p53 mutants (R248W: COLO 320DM and NCI-H1770; R248Q: HCC70 and OVCAR-3; R175H: LS123; R273H: HT-29 and ARH-77; Y220C: NCI-H748 and NCI-H2342; and R280K: MDA-MB-231).
ADH-6 causes death of cancer cells bearing mutant, but not WT p53, induces transcriptional reactivation of p53.
ADH-6 ((716.4 uM, i.p.) causes regression of mutant p53-bearing tumors in the MIA PaCa-2 xenografts with no adversely effect on body weight, did not significantly alter the amount of WT p53 in MCF-7 xenografts.

物理化学性质&存储条件

分子量 640.654
分子式 C29H36N8O9
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

methyl 6-(3-aminopropoxy)-5-(6-(3-aminopropoxy)-5-(6-butoxy-5-nitropicolinamido)picolinamido)picolinate

参考文献

1. L Palanikumar, et al. Nat Commun. 2021 Jun 25;12(1):3962.

备案号：沪ICP备16042516号-1 Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

联系我们 sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

询单

  • *产品名称:
  • *姓名:
  • *邮箱:
  • *公司名称:
  • *询单数量:
  • *国籍:
  • 询单信息: