SAR405838 |CAS:1303607-60-4 Probechem Biochemicals

Chemical Structure : SAR405838

CAS No.: 1303607-60-4

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SAR405838 (MI-77301, MI-773, SAR-405838)

货号: PC-45588Not For Human Use, Lab Use Only.

SAR405838 (MI-77301, MI-773) is a potent and highly selective small-molecule inhibitor of MDM2-p53 interaction with Ki of 0.88 nM.

规格	价格	库存
5 mg	￥1280	In stock
10 mg	￥1980	In stock
25 mg	￥3480	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

SAR405838 (MI-77301, MI-773) is a potent and highly selective small-molecule inhibitor of MDM2-p53 interaction with Ki of 0.88 nM.
SAR405838 activates wild-type p53 in vitro and causes p53-dependent cell-cycle arrest and/or apoptosis.
SAR405838 shows durable tumor regression or complete tumor growth inhibition in mouse xenograft models of SJSA-1 osteosarcoma, RS4;11 acute leukemia, LNCaP prostate cancer, and HCT-116 colon cancer; orally bioactive.

物理化学性质&存储条件

分子量	562.503
分子式	C29H34Cl2FN3O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Spiro[3H-indole-3,3'-pyrrolidine]-5'-carboxamide, 6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-(2,2-dimethylpropyl)-1,2-dihydro-N-(trans-4-hydroxycyclohexyl)-2-oxo-, (2'S,3R,4'S,5'R)-

参考文献

1. Wang S, et al. Cancer Res. 2014 Oct 15;74(20):5855-65.

2. Bill KL, et al. Clin Cancer Res. 2016 Mar 1;22(5):1150-60.

3. Lu J, et al. Oncotarget. 2016 Dec 13;7(50):82757-82769.

SAR405838 (MI-77301, MI-773, SAR-405838)

生物&药学活性

物理化学性质&存储条件

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SAR405838 (MI-77301, MI-773, SAR-405838)

生物&药学活性

物理化学性质&存储条件

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