PhiKan 083 |CAS:1050480-30-2 Probechem Biochemicals

Chemical Structure : PhiKan 083

CAS No.: 1050480-30-2

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PhiKan 083 (PK-083, PhiKan-083)

货号: PC-70006Not For Human Use, Lab Use Only.

PhiKan 083 is a small-molecule stabilizer of p53 mutant Y220C with Kd of 150 uM.

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5 mg	￥880	In stock
10 mg	￥1280	In stock
25 mg	￥2180	In stock
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生物&药学活性

PhiKan 083 is a small-molecule stabilizer of p53 mutant Y220C with Kd of 150 uM.
PhiKan 083 binds with high affinity to a crevice created by the Y220C mutation in p53 and stabilizes the mutant protein.

物理化学性质&存储条件

分子量	274.792
分子式	C16H18N2.HCl
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(9-ethyl-9H-carbazol-3-yl)-N-methylmethanamine hydrochloride

参考文献

1. Bauer MR, et al. ACS Chem Biol. 2016 Aug 19;11(8):2265-74.

2. Boeckler FM, et al. Proc Natl Acad Sci U S A. 2008 Jul 29;105(30):10360-5.

3. Wiman KG. Oncogene. 2010 Jul 29;29(30):4245-52.

PhiKan 083 (PK-083, PhiKan-083)

生物&药学活性

物理化学性质&存储条件

参考文献

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PhiKan 083 (PK-083, PhiKan-083)

生物&药学活性

物理化学性质&存储条件

参考文献

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