RVJB59 | p53 activator | Probechem Biochemicals

Chemical Structure : RVJB59

加入收藏

RVJB59 (RVJB-59)

货号: PC-28029Not For Human Use, Lab Use Only.

RVJB59 is a covalent small molecule activator of wtP53 and p53 mutants, shows selective covalent binding to Cys 141 of wt p53DBD.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

RVJB59 is a covalent small molecule activator of wtP53 and p53 mutants, shows selective covalent binding to Cys 141 of wt p53DBD.
RVJB59 thermally stabilizes the R280K mutant p53 in a dose-dependent manner in differential scanning fluorimetry assays.
RVJB59 enhances the thermostability of the wt and R273H p53 DNA-binding domain.
RVJB59 is selective for cancer cells and may reactivate p53 in mutant p53 cells in cancer cell line expressing R273H mutant p53 (HT29) and in fibroblasts.
RVJB59 reduced 3D tumor spheroid growth and showed antiangiogenic potential.

物理化学性质&存储条件

分子量	459.89
分子式	C25H18ClN3O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(3R,9bS)-3-((1H-indol-3-yl)methyl)-9b-(4-chloro-3-nitrophenyl)- 2,3-dihydrooxazolo[2,3-a]isoindol-5(9bH)-one

参考文献

1. Ferreira RJF, et al. ACS Pharmacol Transl Sci. 2025 May 7;8(6):1726-1740.

2. Ferreira RJF, et al. ChemMedChem. 2026 Sep 14;21(17):e70483.

RVJB59 (RVJB-59)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

RVJB59 (RVJB-59)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.