| Cat. No. |
Product Name |
Information |
| PC-35595 |
R191
IRAK1/4 inhibitor
|
R191 (R-191) is a potent, small molecule IRAK1/4 kinase inhibitor (IRAK4 IC50=3 nM), exhibits good selectivity against a broad panel of kinases. |
| PC-35553 |
PF-06426779
IRAK4 inhibitor
|
PF-06426779 (PF06426779) is a potent, selective IRAK4 inhibitor with IC50 of 1 nM against full-length IRAK4 kinase and cell-based IC50 of 12 nM. |
| PC-35135 |
Compound 7004
IRAK2 mimetic
|
Compound 7004 (IRAK2 mimetic 7004) is a small molecule mimetic of a-helical domain of IRAK2, inhibit IL-33–induced NF-κB transcriptional activity (IC50=9.7 uM) by disrupting Myddosome formation. |
| PC-43498 |
IRAK-1-4 Inhibitor I
IRAK1/4 inhibitor
|
IRAK-1-4 Inhibitor I is a potent, dual inhibitor of IRAK4 and IRAK1 with IC50 of 0.2 uM and 0.3 uM, respectively. |
| PC-43455 |
IRAK inhibitor 2
IRAK4 inhibitor
|
IRAK inhibitor 2 is a potent IRAK4 inhibitor. |
| PC-43454 |
IRAK inhibitor 1
IRAK4 inhibitor
|
IRAK inhibitor 1 is a potent IRAK4 inhibitor with IC50 of 216 nM, shows little to no activity against JNK-1 and JNK-2 with IC50 of 3.801 uM and >10 uM, respectively. |
| PC-63079 |
BMS-986126
IRAK4 inhibitor
|
BMS-986126 is a potent, highly selective inhibitor of IRAK4 kinase with IC50 of 5.3 nM, displays >100-fold selective for IRAK4 over a panel of 214 kinases. |
| PC-61623 |
IRAK4 inhibitor 23
IRAK4 inhibitor
|
IRAK4 inhibitor 23 is a potent, selective, orally bioavailable IRAK4 inhibitor with IC50 of 7 nM. |
| PC-61092 |
PF-05387252
IRAK4 inhibitor
|
A potent, selective IRAK4 inhibitor with IC50 of 1.3 nM, 200-fold selectivity over IRAK1 (IC50=290 nM). |
| PC-61091 |
PF-05388169
IRAK4 inhibitor
|
PF-05388169 is a potent, selective IRAK4 inhibitor with IC50 of 0.094 nM, >500-fold selectivity over IRAK1 (IC50=65 nM). |
| PC-60997 |
AS2444697
IRAK4 inhibitor
|
AS2444697 is a potent, selective, orally bioavailable IRAK4 inhibitor (IC50=21 nM), potently inhibits human and rat IRAK-4 activity with subnanomolar order, >30-fold selectivity over IRAK-1. |
| PC-60980 |
IRAK4-IN-16
IRAK4 inhibitor
|
IRAK4-IN-16 is a potent, selective, and orally bioavailable inhibitor of interleukin-1 receptor-associate kinase-4 (IRAK4) with IC50 of 2.8 nM, 217- and 892-fold selectivity over IRAK-1 and TAK1, respectively. |
