IRAK-1-4 Inhibitor I | IRAK1/4 inhibitor | Probechem Biochemicals

Chemical Structure : IRAK-1-4 Inhibitor I

CAS No.: 509093-47-4

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IRAK-1-4 Inhibitor I (IRAK-1/4 Inhibitor I)

货号: PC-43498Not For Human Use, Lab Use Only.

IRAK-1-4 Inhibitor I is a potent, dual inhibitor of IRAK4 and IRAK1 with IC50 of 0.2 uM and 0.3 uM, respectively.

规格	价格	库存
10 mg	￥980	In stock
25 mg	￥1580	In stock
50 mg	￥2480	In stock
100 mg		Get quote

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生物&药学活性

IRAK-1-4 Inhibitor I is a potent, dual inhibitor of IRAK4 and IRAK1 with IC50 of 0.2 uM and 0.3 uM, respectively.
IRAK-1-4 Inhibitor I displays IC50 of >10 uM against a panel of 27 other kinases, including the most closely homologous (outside of the IRAK family) Lck and pp60SRC.
IRAK-1-4 Inhibitor I eliminates the LPS-induced increases in Bcl10, NF-κB, and IL-8 in human intestinal epithelial cells.

物理化学性质&存储条件

分子量	395.41
分子式	C20H21N5O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Benzamide, N-[1-[2-(4-morpholinyl)ethyl]-1H-benzimidazol-2-yl]-3-nitro-

参考文献

1. Powers JP, et al. Bioorg Med Chem Lett. 2006 Jun 1;16(11):2842-5.

2. Bhattacharyya S, et al. Am J Physiol Gastrointest Liver Physiol. 2007 Aug;293(2):G429-37.

IRAK-1-4 Inhibitor I (IRAK-1/4 Inhibitor I)

生物&药学活性

物理化学性质&存储条件

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IRAK-1-4 Inhibitor I (IRAK-1/4 Inhibitor I)

生物&药学活性

物理化学性质&存储条件

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