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首页-小分子抑制剂&激动剂-Immunology/Inflammation-IRAK-Zabedosertib
Zabedosertib

Chemical Structure : Zabedosertib

CAS No.: 1931994-81-8

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Zabedosertib (BAY1834845, BAY-1834845)

货号: PC-38683Not For Human Use, Lab Use Only.

Zabedosertib (BAY1834845) is a potent, selective IRAK4 inhibitor with IC50 of 3.4 nM, inhibits IRAK4 mediated activation of the TLR/MYD88 pathway.

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10 mg ￥1480 In stock
25 mg ￥2680 In stock
50 mg ￥4480 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Zabedosertib (BAY1834845) is a potent, selective IRAK4 inhibitor with IC50 of 3.4 nM, inhibits IRAK4 mediated activation of the TLR/MYD88 pathway.

物理化学性质&存储条件

分子量 470.47
分子式 C20H21F3N4O4S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-{6-(2-hydroxypropan-2-yl)-2-[2-(methanesulfonyl)ethyl]- 2H-indazol-5-yl}-6-(trifluoromethyl)pyridine-2- carboxamide

参考文献

1. Bothe U, et al. J Med Chem. 2024 Jan 25;67(2):1225-1242.

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