Chemical Structure : HS-243
CAS No.: 848249-10-5
货号: PC-73131Not For Human Use, Lab Use Only.
HS-243 (HS243) is a highly potent, super-selective IRAK-1/4 inhibitor with IC50 of 24/20 nM, respectively.
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5 mg | ¥980 | In stock | |
10 mg | ¥1480 | In stock | |
25 mg | ¥2580 | In stock | |
50 mg | ¥3980 | In stock | |
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HS-243 (HS243) is a highly potent, super-selective IRAK-1/4 inhibitor with IC50 of 24/20 nM, respectively.
HS-243 shows exquisite potency toward IRAK-1/4 over all other human kinases with only minimal TAK1-inhibiting activity (IC50=0.5 uM).
HS-243 binds in the ATP-binding pocket of IRAK-4.
HS-243 potently reduces the proinflammatory response of RA cells and macrophages, has distinct cytokine profile from TAK1.
HS-243 reduces percentage of survival in pancreatic and breast cancer cell lines.
分子量 | 324.34 | |
分子式 | C17H16N4O3 | |
外观性状 | Solid | |
储存条件 |
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Solubility |
10 mM in DMSO |
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Chemical Name/SMILES |
3-Nitro-N-(1-propyl-1H-benzo[d]imidazol-2-yl)benzamide |
1. Scarneo SA, et al. J Biol Chem. 2020 Feb 7;295(6):1565-1574.
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