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首页-小分子抑制剂&激动剂-Immunology/Inflammation-IRAK-HS-243
HS-243

Chemical Structure : HS-243

CAS No.: 848249-10-5

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HS-243 (HS243)

货号: PC-73131Not For Human Use, Lab Use Only.

HS-243 (HS243) is a highly potent, super-selective IRAK-1/4 inhibitor with IC50 of 24/20 nM, respectively.

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5 mg ￥980 In stock
10 mg ￥1480 In stock
25 mg ￥2580 In stock
50 mg ￥3980 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

HS-243 (HS243) is a highly potent, super-selective IRAK-1/4 inhibitor with IC50 of 24/20 nM, respectively.
HS-243 shows exquisite potency toward IRAK-1/4 over all other human kinases with only minimal TAK1-inhibiting activity (IC50=0.5 uM).
HS-243 binds in the ATP-binding pocket of IRAK-4.
HS-243 potently reduces the proinflammatory response of RA cells and macrophages, has distinct cytokine profile from TAK1.
HS-243 reduces percentage of survival in pancreatic and breast cancer cell lines.

物理化学性质&存储条件

分子量 324.34
分子式 C17H16N4O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

3-Nitro-N-(1-propyl-1H-benzo[d]imidazol-2-yl)benzamide

参考文献

1. Scarneo SA, et al. J Biol Chem. 2020 Feb 7;295(6):1565-1574.

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