JH-X-119-01 | IRAK1 inhibitor | Probechem Biochemicals

Chemical Structure : JH-X-119-01

CAS No.: 2227368-54-7

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JH-X-119-01 (IRAK1 inhibitor)

货号: PC-38073Not For Human Use, Lab Use Only.

JH-X-119-01 is a highly potent, selective and covalent inhibitor of IRAK1 with IC50 of 9 nM.

规格	价格	库存
5 mg	￥1380	In stock
10 mg	￥2180	In stock
25 mg	￥3780	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

JH-X-119-01 is a highly potent, selective and covalent inhibitor of IRAK1 with IC50 of 9 nM.
JH-X-119-01 irreversibly and covalently labels IRAK1 at C302.
JH-X-119-01 displays no inhibition of IRAK4 at 10 uM, shows exceptional kinome selectivity as assessed by KinomeScan (468 kinases) at 1 μM with off-target inhibition of only two additional kinases, YSK4 (IC50=57 nM) and MEK3.
JH-X-119-01 exhibits moderate cell killing effects in a panel of WM cells, DLBCL cells, and lymphoma cells expressing MYD88.

物理化学性质&存储条件

分子量	452.474
分子式	C25H20N6O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-(3-Acrylamidobenzamido)phenyl)-6-(1H-pyrazol-5-yl)picolinamide

参考文献

1. Pan B, et al. Int Immunopharmacol. 2020 Aug;85:106597.

2. Hatcher JM, et al. ACS Med Chem Lett. 2020 Oct 9;11(11):2238-2243.

3. Gao J, et al. Transplant Cell Ther. 2022 Mar;28(3):134.e1-134.e10.

JH-X-119-01 (IRAK1 inhibitor)

生物&药学活性

物理化学性质&存储条件

参考文献

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JH-X-119-01 (IRAK1 inhibitor)

生物&药学活性

物理化学性质&存储条件

参考文献

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