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首页-小分子抑制剂&激动剂-Immunology/Inflammation-IRAK-Compound 7004
Compound 7004

Chemical Structure : Compound 7004

CAS No.:

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Compound 7004 (IRAK2 mimetic 7004)

货号: PC-35135Not For Human Use, Lab Use Only.

Compound 7004 (IRAK2 mimetic 7004) is a small molecule mimetic of a-helical domain of IRAK2, inhibit IL-33–induced NF-κB transcriptional activity (IC50=9.7 uM) by disrupting Myddosome formation.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    Compound 7004 (IRAK2 mimetic 7004) is a small molecule mimetic of a-helical domain of IRAK2, inhibit IL-33-induced NF-κB transcriptional activity (IC50=9.7 uM) by disrupting Myddosome formation.
    Compound 7004 decreases the IRAK2-IRAK4 association, attenuates IL-33-induced and OVA-induced asthma mouse models in vivo.
    Compound 7004 attenuates the proinflammatory effects in asthma-like models.

    物理化学性质&存储条件

    分子量
    分子式
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    参考文献

    1. Li J, et al. J Immunol. 2018 May 4. pii: ji1700693.

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