HG-12-6 |CAS:2222354-57-4 Probechem Biochemicals

Chemical Structure : HG-12-6

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HG-12-6 (IRAK4 inhibitor)

货号: PC-36036Not For Human Use, Lab Use Only.

HG-12-6 is a small-molecule inhibitor that bind preferentially to unphosphorylated IRAK4 with IC50 of 165.1 nM, displays 15-fold selectivity over phosphorylated IRAK4 (IC50=2876 nM).

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25 mg		Get quote
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生物&药学活性

HG-12-6 is a small-molecule inhibitor that bind preferentially to unphosphorylated IRAK4 with IC50 of 165.1 nM, displays 15-fold selectivity over phosphorylated IRAK4 (IC50=2876 nM).
HG-12-6 binds as type II inhibitor with IRAK4 in a “DFG-out” conformation.

物理化学性质&存储条件

分子量	580.63
分子式	C29H27F3N6O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(2-(cyclopropanecarboxamido)thiazolo[5,4-b]pyridin-5-yl)-N-(4-(piperazin-1-ylmethyl)-3-(trifluoromethyl)phenyl)benzamide

参考文献

1. Wang L, et al. J Biol Chem. 2019 Jan 24. pii: jbc.RA118.005428. doi: 10.1074/jbc.RA118.005428.

HG-12-6 (IRAK4 inhibitor)

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物理化学性质&存储条件

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HG-12-6 (IRAK4 inhibitor)

生物&药学活性

物理化学性质&存储条件

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