ND-2110 | IRAK4 inhibitor | Probechem Biochemicals

Chemical Structure : ND-2110

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ND-2110 (ND2110)

货号: PC-49046Not For Human Use, Lab Use Only.

ND2110 is a highly selective and bioavailable small molecule IRAK4 inhibitor with IC50 of 7.5 nM, no significant activity against IRAK1 (IC50>2000 nM).

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

ND2110 is a highly selective and bioavailable small molecule IRAK4 inhibitor with IC50 of 7.5 nM, no significant activity against IRAK1 (IC50>2000 nM).
ND2110 blocks TNF production, collagen-induced arthritis, and gout formation in mice.
ND2110 reduces in vitro viability of multiple ABC DLBCL lines, targets the subset of ABC DLBCL lines with MYD88 L265P mutations, but not ABC DLBCL lines with other MYD88 mutations (S222R and S219C) or those with WT MYD88.

物理化学性质&存储条件

分子量	416.54
分子式	C21H28N4O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(5R)-6,7-Dihydro-4-[[trans-4-(4-morpholinyl)cyclohexyl]oxy]-5H-cyclopenta[4,5]thieno[2,3-d]pyrimidine-5-acetamide

参考文献

1. Priscilla N Kelly, et al. J Exp Med. 2015 Dec 14;212(13):2189-201.

ND-2110 (ND2110)

生物&药学活性

物理化学性质&存储条件

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ND-2110 (ND2110)

生物&药学活性

物理化学性质&存储条件

参考文献

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