BIO-8169 | IRAK4 inhibitor | Probechem Biochemicals

Chemical Structure : BIO-8169

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BIO-8169 (BIO 8169)

货号: PC-22268Not For Human Use, Lab Use Only.

规格	价格	库存	数量
25 mg		Get quote
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100 mg		Get quote
250 mg		Get quote

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生物&药学活性

BIO-8169 is a highly potent, selective, brain-penetrant and oral bioavailable IRAK4 inhibitor with IC50 of 0.23 nM, potently inhibits R848 stimulated IL-1β production with IC50 of 246 nM in HWB assays.
BIO-8169 displays high selectivity in a broad kinome panel (Eurofins: 468 kinases) at 1 uM, only three kinases in the panel shows greater than 80% inhibition (FLT3: 418 nM, TRKA: 752 nM, TRKB: 1155 nM).
BIO-8169 has an excellent PK profile, reduces the in vivo production of pro-inflammatory cytokines, and is tolerated in toxicity studies in rodents and dogs at margins.
BIO-8169 (30 mg/kg QD and 20 mg/kg BID) inhibited the development of EAE with concomitant reduction of number of inflammatory foci, T cell infiltrates, and activated microglial and macrophage density, in mouse model of human multiple sclerosis.

物理化学性质&存储条件

分子量	449.51
分子式	C24H27N5O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(1-cyclopropyl-2-oxo-1,2-dihydropyridin-3-yl)-7-isopropoxy-2-(1-methyl-2-oxabicyclo[2.1.1]hexan-4-yl)imidazo[1,2-a]pyrimidine-6-carboxamide

参考文献

1. Pfaffenbach M, et al. J Med Chem. 2024 May 2. doi: 10.1021/acs.jmedchem.4c00560.

BIO-8169 (BIO 8169)

生物&药学活性

物理化学性质&存储条件

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BIO-8169 (BIO 8169)

生物&药学活性

物理化学性质&存储条件

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