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首页-小分子抑制剂&激动剂-Immunology/Inflammation-IRAK-BIO-7488
BIO-7488

Chemical Structure : BIO-7488

CAS No.: 2573211-25-1

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BIO-7488 (BIO7488, BIO 7488)

货号: PC-21921Not For Human Use, Lab Use Only.

BIO-7488 (BIO7488) is the first potent, selective, and CNS-penetrant IRAK4 inhibitor with IC50 of 0.5 nM (1 mM ATP).

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

BIO-7488 (BIO7488) is the first potent, selective, and CNS-penetrant IRAK4 inhibitor with IC50 of 0.5 nM (1 mM ATP).
BIO-7488 potently inhibits R848 stimulus of 1L-1β production with IC50 of 200 nM in human whole blood assay.
BIO-7488 has limited MDR1 or BCRP efflux liability, supporting the favorable measured rat Kpu,u of 0.3 in rats.
BIO-7488 (10, 30, or 100 mg/kg) demonstrated robust and dose-dependent suppression of multiple cytokines, including IL-1β, TNFα, and IL-6 in LPS challenge rat model.

物理化学性质&存储条件

分子量 447.50
分子式 C23H25N7O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

7-Isopropoxy-2-(1-methyl-2-oxabicyclo[2.1.1]hexan-4-yl)- N-(6-methylpyrazolo[1,5- a]pyrimidin-3-yl)imidazo[1,2- a]pyrimidine-6-carboxamide

参考文献

1. Ryan Evans, et al. J Med Chem. 2024 Mar 11. doi: 10.1021/acs.jmedchem.3c02226.

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