SKLB-11A

Chemical Structure : SKLB-11A

加入收藏

货号: PC-24824Not For Human Use, Lab Use Only.

SKLB-11A is a specific, allosteric small molecule SIRT3 activator, directly targets and activates SIRT3 with EC50 of 21.95 uM, effectively binds to SIRT3 with SPR Kd of 4.7 uM.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

SKLB-11A is a specific, allosteric small molecule SIRT3 activator, directly targets and activates SIRT3 with EC50 of 21.95 uM, effectively binds to SIRT3 with SPR Kd of 4.7 uM.
SKLB-11A induces deacetylation at K122 and K68, resulting in enhanced MnSOD enzymatic activity in H9c2 cells.
SKLB-11A shows no binding to SIRT5 or SIRT6, displays some binding affinity for SIRT1 and SIRT2 (KD>200 μM), approximately 40 times lower than its affinity for SIRT3.
SKLB-11A binds to SIRT3 with high affinity and enhances its interaction with the p53-Ac substrate.
SKLB-11A (5-20 uM) improves mitochondrial function and induces autophagy/mitophagy in H9c2 cells.
SKLB-11A (10 or 20 mg/kg, ig) demonstrates cardioprotective effects in Dox-induced cardiotoxicity models in vivo.

物理化学性质&存储条件

分子量	350.35
分子式	C19H15FN4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	methyl 2-amino-1-(4-fluorobenzyl)-1H-pyrrolo[2,3-b]quinoxaline-3-carboxylate

参考文献

1. Dan Zhang, et al. ACS Cent Sci. 2025 Apr 14;11(5):704-718.

SKLB-11A

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

SKLB-11A

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.