Forvisirvat | SIRT6 activator | Probechem Biochemicals

Chemical Structure : Forvisirvat

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Forvisirvat (SP-624, SP624)

货号: PC-25052Not For Human Use, Lab Use Only.

Forvisirvat (SP‐624) is a selective, orally active sirtuin 6 (SIRT6) activator.

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生物&药学活性

Forvisirvat (SP‐624) is a selective, orally active sirtuin 6 (SIRT6) activator.
SP‐624 activates SIRT6 deacetylation of histone peptides and deacetylation of H3K9 and H3K18 in intact nucleosomes.
SP‐624 is active in multiple animal models used to predict efficacy for depression in humans, including tests in adrenocorticotropic hormone‐treated mice and olfactory bulbectomized rats.
SP‐624 also prevents cognitive deficits induced by scopolamine (anticholinergic) or phencyclidine (N‐methyl‐D‐aspartate antagonist) in the novel object recognition test and suppressed excessive cytokine release in animal models.

物理化学性质&存储条件

分子量	404.80
分子式	C19H17ClN2O6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2S,6'R)-7-chloro-2',4-dimethoxy-6'-methyl-6-(5-methyl-1,3,4-oxadiazol-2-yl)-3H-spiro[benzofuran-2,1'-cyclohexan]-2'-ene-3,4'-dione

参考文献

1. Greg Rigdon, et al. Clin Pharmacol Drug Dev. 2025 Jan;14(1):18-25.

2. Patent WO2024168215 A1.

Forvisirvat (SP-624, SP624)

生物&药学活性

物理化学性质&存储条件

参考文献

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Forvisirvat (SP-624, SP624)

生物&药学活性

物理化学性质&存储条件

参考文献

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