Forvisirvat (DS-7830a, SP-624) | SIRT6 activator | Probechem Biochemicals

Chemical Structure : Forvisirvat

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Forvisirvat (DS-7830a, DS7830a, SP-624, SP624)

货号: PC-25052Not For Human Use, Lab Use Only.

Forvisirvat (SP-624) is a selective, orally active sirtuin 6 (SIRT6) activator with EC150 of 1.2 uM.

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100 mg		Get quote

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生物&药学活性

Forvisirvat (SP-624) is a selective, orally active sirtuin 6 (SIRT6) activator with EC150 of 1.2 uM.
SP-624 activates SIRT6 deacetylation of histone peptides and deacetylation of H3K9 and H3K18 in intact nucleosomes.
SP-624 is active in multiple animal models used to predict efficacy for depression in humans, including tests in adrenocorticotropic hormone‐treated mice and olfactory bulbectomized rats.
SP-624 also prevents cognitive deficits induced by scopolamine (anticholinergic) or phencyclidine (N-methyl-D-aspartate antagonist) in the novel object recognition test and suppressed excessive cytokine release in animal models.

物理化学性质&存储条件

分子量	404.80
分子式	C19H17ClN2O6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2S,6'R)-7-chloro-2',4-dimethoxy-6'-methyl-6-(5-methyl-1,3,4-oxadiazol-2-yl)-3H-spiro[benzofuran-2,1'-cyclohexan]-2'-ene-3,4'-dione

参考文献

1. Greg Rigdon, et al. Clin Pharmacol Drug Dev. 2025 Jan;14(1):18-25.

2. Patent WO2024168215 A1.

Forvisirvat (DS-7830a, DS7830a, SP-624, SP624)

生物&药学活性

物理化学性质&存储条件

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Forvisirvat (DS-7830a, DS7830a, SP-624, SP624)

生物&药学活性

物理化学性质&存储条件

参考文献

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