SRT1720 hydrochloride

Chemical Structure : SRT1720 hydrochloride

CAS No.: 1001645-58-4

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货号: PC-21902Not For Human Use, Lab Use Only.

SRT 1720 Hcl is a potent, selective SIRT1 activator with EC1.5 of 0.16 uM.

规格	价格	库存
25 mg	￥1280	In stock
50 mg	￥1880	In stock
100 mg	￥2980	In stock
200 mg		Get quote
1 g		Get quote

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生物&药学活性

SRT1720 hydrochloride is a potent, selective SIRT1 activator with EC1.5 of 0.16 uM.
SRT 1720 displays good selectivity for activation of SIRT1 versus SIRT2 (EC1.5=37 uM) and SIRT3 (EC1.5>300 uM).
SRT 1720 is 1,000-fold more potent than resveratrol.
SRT 1720 improves insulin sensitivity, lower plasma glucose, and increases mitochondrial capacity in obese mice model.

物理化学性质&存储条件

分子量	506.02
分子式	C25H24ClN7OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(2-(3-(Piperazin-1-ylmethyl)imidazo[2,1-b]thiazol-6-yl)phenyl)quinoxaline-2-carboxamide hydrochloride

参考文献

1. Milne JC, et al. Nature. 2007 Nov 29;450(7170):712-6.

2. Pacholec M, et al. J Biol Chem. 2010 Mar 12;285(11):8340-51.