SIRT3 activator SZC-6

Chemical Structure : SIRT3 activator SZC-6

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货号: PC-25567Not For Human Use, Lab Use Only.

SIRT3 activator SZC-6 is a selective small molecule SIRT3 activator, increases SIRT3 deacetylation activitywith EC50 of 23.2 uM, binds directly to SIRT3 with SPR KD of 15 uM.

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250 mg		Get quote

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生物&药学活性

SIRT3 activator SZC-6 is a selective small molecule SIRT3 activator, increases SIRT3 deacetylation activitywith EC50 of 23.2 uM, binds directly to SIRT3 with SPR KD of 15 uM.
SZC-6 activates SIRT3 and deacetylates mitochondrial proteins in cardiomyocytes.
SZC-6 considerably increases SIRT3 deacetylation activity by more than 20-fold at 100 μM.
SZC-6 shows no effects on SIRT1 and Nampt.
SZC-6 attenuates stress-induced hypertrophic responses in cardiomyocytes in a dose-dependent manner.
SZC-6 (60 mg/kg/day) attenuates pathological hypertrophy of wild type, but not SIRT3-KO mice.

物理化学性质&存储条件

分子量	333.14
分子式	C15H9BrO4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(2-bromo-4-hydroxyphenyl)-7-hydroxy-2H-chromen-2-one

参考文献

1. Li ZY, et al. Acta Pharmacol Sin. 2023 Mar;44(3):546-560.