2-APQC | SIRT3 activator | Probechem Biochemicals

Chemical Structure : 2-APQC

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2-APQC (SIRT3 activator 2-APQC)

货号: PC-22370Not For Human Use, Lab Use Only.

2-APQC is a specific, small-molecule activator of Sirtuin-3 (SIRT3), binds to (SPR KD=2.76 uM) and activates SIRT3 deacetylation activity.

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生物&药学活性

2-APQC is a specific, small-molecule activator of Sirtuin-3 (SIRT3), binds to (SPR KD=2.76 uM) and activates SIRT3 deacetylation activity.
2-APQC exhibits no apparent cytotoxicity even at 40 µM.
2-APQC could effectively ameliorate myocardial injury induced by isoproterenol (ISO).
2-APQC improved the thermal stability of SIRT3 in H9c2 cells as cellular thermal shift assay (CETSA) assays, does not significantly affect the expression of SIRTs, including SIRT1, SIRT2, SIRT4, SIRT5, SIRT6 and SIRT7.
2-APQC improves heart failure (HF) by relieving myocardial hypertrophy and inhibiting myocardial fibrosis in ISO-induced heart failure (HF) model in vitro and in vivo, could not alleviate ISO-induced HF in SIRT3 knockout mouse model.
2-APQC plays a protective role in ISO-induced heart injury by SIRT3-pyrroline-5-carboxylate reductase 1 (PYCR1) regulated mitochondrial oxidative stress and SIRT3-RIPK3-modulated necrosis.

物理化学性质&存储条件

分子量	405.48
分子式	C23H24FN5O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-amino-1-(4-fluorobenzyl)-N-pentyl-1H-pyrrolo[2,3-b]quinoxaline-3-carboxamide

参考文献

1. Peng F, et al. Signal Transduct Target Ther. 2024 May 15;9(1):133.

2-APQC (SIRT3 activator 2-APQC)

生物&药学活性

物理化学性质&存储条件

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2-APQC (SIRT3 activator 2-APQC)

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物理化学性质&存储条件

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