SIRT6 inhibitor 11e | SIRT6 inhibitor | Probechem Biochemicals

Chemical Structure : SIRT6 inhibitor 11e

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SIRT6 inhibitor 11e (SIRT6 inhibitor Compound 11e)

货号: PC-21990Not For Human Use, Lab Use Only.

SIRT6 inhibitor 11e (Compound 11e) is a potent, selective and allosteric SIRT6 inhibitor with IC50 of 0.98 uM, directly binds to SIRT6 with Kd of 9.46 uM, inhibits pancreatic cancer metastasis in vitro and vivo.

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100 mg		Get quote

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生物&药学活性

SIRT6 inhibitor 11e (Compound 11e) is a potent, selective and allosteric SIRT6 inhibitor with IC50 of 0.98 uM, directly binds to SIRT6 with Kd of 9.46 uM, inhibits pancreatic cancer metastasis in vitro and vivo.
SIRT6 inhibitor 11e deos not affect the enzymatic activity of SIRT1, SIRT2, SIRT3, and HDAC1-11 at 100 uM.
SIRT6 inhibitor 11e (0-20 uM) upregulates the acetylation levels of H3K9, H3K18, and H3K56 in a concentration-dependent manner in human-derived cell line BxPC-3 and the murine-derived cell line PANC-02.
SIRT6 inhibitor 11e (20 uM) completely blocks the migration of BxPC-3 or PANC-02 cells, which is more potent than JYQ-42 (Cat#PC-49248, 40 uM reached).
SIRT6 inhibitor 11e moderate dose (10 mg/kg, i.p.) displaysmarked inhibition of liver metastases, the high dose of 30 mg/kg shows no obvious weight loss or hepatotoxicity or renal toxicity in mouse-derived pancreatic cancer cells PANC-02, inhibits the metastasis of mouse-derived pancreatic cancer.

物理化学性质&存储条件

分子量	480.89
分子式	C22H16ClF3N2O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-((4-((3-chlorophenyl)thio)-3-(trifluoromethyl)benzyl)oxy)terephthalamide

参考文献

1. Xinyuan Xu, et al. Acta Pharm Sin B. 2024 Mar;14(3):1302-1316.

SIRT6 inhibitor 11e (SIRT6 inhibitor Compound 11e)

生物&药学活性

物理化学性质&存储条件

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SIRT6 inhibitor 11e (SIRT6 inhibitor Compound 11e)

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物理化学性质&存储条件

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